Search results for "Serum Response Element"

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DeepSRE: Identification of sterol responsive elements and nuclear transcription factors Y proximity in human DNA by Convolutional Neural Network anal…

2021

SREBP1 and 2, are cholesterol sensors able to modulate cholesterol-related gene expression responses. SREBPs binding sites are characterized by the presence of multiple target sequences as SRE, NFY and SP1, that can be arranged differently in different genes, so that it is not easy to identify the binding site on the basis of direct DNA sequence analysis. This paper presents a complete workflow based on a one-dimensional Convolutional Neural Network (CNN) model able to detect putative SREBPs binding sites irrespective of target elements arrangements. The strategy is based on the recognition of SRE linked (less than 250 bp) to NFY sequences according to chromosomal localization derived from …

Metabolic ProcessesSettore MED/09 - Medicina InternaConservation BiologyGene ExpressionBiochemistryConservation ScienceData ManagementRegulation of gene expressionMultidisciplinaryGene OntologiesQRGenomicsLipidsPhylogeneticsCholesterolConservation GeneticsMedicineSettore MED/46 - Scienze Tecniche Di Medicina Di LaboratorioResearch ArticleComputer and Information SciencesSp1 Transcription FactorSequence analysisScienceDNA transcriptionComputational biologyBiologyData mining Deep Learning Genetics Transcription factorDNA-binding proteinsGeneticsHumansGene RegulationEvolutionary SystematicsBinding siteGeneTranscription factorTaxonomyEvolutionary BiologyModels GeneticEcology and Environmental SciencesBiology and Life SciencesComputational BiologyProteinsPromoterDNA PatternsDNASequence Analysis DNAGenome AnalysisRegulatory ProteinsSterol regulatory element-binding proteinMetabolismSerum Response ElementCCAAT-Binding FactorTranscription Factors
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